MITOCHONDRIAL ANTIOXIDANT PREVENTS METABOLIC AND RENAL DYSFUNCTION INDUCED BY MATERNAL SMOKING

G LI1,2,3, C LUNG2, S SUKJAMNONG1, B OLIVER1,2, S SAAD1,3, H CHEN1
1University Of Technology Sydney, Sydney, Australia, 2Woolcock Institute of Medical Research, Sydney, Australia, 3Kolling Institute of Medical Research, Sydney, Australia

Background: Maternal smoking during pregnancy leads to range of health complications in the offspring including type 2 diabetes and chronic kidney disease. Previous studies from our team suggest that the development of these conditions are closely related to tissue mitochondrial damage induced by maternal smoking. MitoQ is a mitochondrial targeted antioxidant, with the potential in treating mitochondrial dysfunction related disorders. However, the impacts of maternal MitoQ supplementation during gestation on metabolic and renal outcomes in offspring from the smoking mothers are unknown.
Aim: To investigate the impacts of maternal MitoQ supplementation on the metabolic and renal disorders induced by maternal smoking in a mouse model.
Methods:Female Balb/c mice were either exposed to air or cigarette smoke for six weeks prior to mating and throughout gestation and lactation. A subset of the cigarette exposed mice were supplemented with MitoQ during gestation and lactation. Male offspring underwent intraperitoneal glucose tolerance test at 12 weeks and kidneys and livers were collected at 13 weeks for further analysis.
Results: Maternal smoking reduced birth weight, kidney weight and liver weight in the offspring. Offspring from smoke exposed mothers also had impaired glucose tolerance, renal pathology combined with abnormal hepatic lipid metabolic markers. Maternal MitoQ supplementation was able to restore birth weight, glucose metabolic disorders, renal pathology and hepatic lipid metabolic markers. Maternal MitoQ supplementation also restored renal and hepatic mitochondrial density and oxidative stress.
Conclusions: Maternal MitoQ supplementation can reverse mitochondrial dysfunction and associated disorders induced by maternal smoking in offspring mice, suggesting a potential therapeutic role of mitochondrial targeted antioxidants in the development of metabolic and renal disease.


Biography:
I am a PhD candidate at the University of Technology Sydney where I am investigating the impacts of maternal cigarette smoke exposure on mitochondrial dysfunction and the related metabolic and renal disorders.

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