RET-He CORRELATED WITH IRON AND TRANSFERRIN SATURATION IN ROUTINE HEMODIALYSIS

M RUDIANSYAH1,5,R ROESLI2, A MARTAKUSUMAH2, R SUPRIYADI2, D RACHMADI3, R BANDIARA2, L LUBIS4
1Division of Nephrology & Hypertension, Department of Internal Medicine  Faculty of Medicine University of Lambung Mangkurat / Ulin General Hospital, Banjarmasin, Indonesia, 2Division of Nephrology & Hypertension, Department of Internal Medicine Faculty of Medicine University of Padjadjaran / Hasan Sadikin Hospital,  Bandung, Indonesia, 3Division of Nephrology and Hypertension, Department of Paediatrics Faculty of Medicine University of Padjadjaran / Hasan Sadikin Hospital, Bandung, Indonesia, 4Department of Anatomy, Physiology, and Cell Biology Faculty of Medicine University of Padjadjaran, Bandung, Indonesia, 5Doctoral Program, Medical Science Faculty of Medicine University of Padjadjaran , Bandung, Indonesia

Aim: to determine the correlation between RET-He and iron levels and transferrin saturation in chronic kidney disease (CKD) patients undergoing routine hemodialysis (CKD-5D).
Background: RET-He is more stable substance, and is not influenced by acute and chronic conditions. A correlation between RET-He as a new and easy parameter and iron levels and transferrin saturation in patients with CKD-5D is required.
Method: This is a cross-sectional study carried out in Hemodialysis Unit of Hasan Sadikin General Hospital Bandung..
Result: There were 181 patients with CKD-5D, 137 patients had complete data and 97 patients who fulfilled inclusion and exclusion criteria taken randomly as study subjects. Characteristics: mean of age 48+13 years, male 53 (54.6%), median of HD vintage 36 (12-168) months, hemoglobin 9.1 (4,7–13,7) gr/dL, serum iron (SI) 54 (14–166) µg/dL, total iron binding capacity (TIBC) 234 (137–429) µg/dL, Trasnferin saturation (TSat) 22.2 (10,1–75,1)% and RET-He 31.7 (19.3–37.5) pg/cell. RET-He correlated with SI (r=0.348, p<0,001) and TSat (r=0.454, p<0,001).
Conclusions: There is significant correlation between SI and Tsat levels with RET-He in CKD-5D patients.
Key words : CKD-5D, Anemia, Iron deficiency, RET-He, Transferin Saturation


Biography:
I am a lecturer in Division of Nephrology and Hypertension, Department of Internal Medicine Faculty of Medicine University of Lambung Mangkurat Banjarmasin / Ulin General Hospital Banjarmasin. I am still study at Doctoral Program, Medical Science Faculty of Medicine University of Padjadjaran Bandung. I interested about anemia, CKD MBD to investigate about how to prevent the complication likely with a traditional medicine ( Eurycoma Longifolia) and inflammation.

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