S BEK1, N EREN1
1Kocaeli University Hospital, Kocaeli, Turkey
Aim: To compare retinal changes of peritoneal dialysis (PD) patients with healthy control group by using optical coherence tomography (OCT) and investigate the effects of age, gender and duration of PD on these parameters.
Background: OCT is a non-invasive ocular imaging technique widely used nowadays. There are limited studies focusing on the OCT findings in PD patients.
Methods: In this cross-sectional study right and left eyes of 32 patients were included. Detailed ophthalmological examinations with central fovea thickness (CFT), macular volume, retinal nerve fiber layer ( RNFL) thickness, and choroidal thickness (using EDI-OCT) were measured. The RNFL thickness was analysed in six different areas: temporal, inferotemporal, inferonasal, nasal, superonasal and superotemporal.
Results: Sixty-four eyes of 32 patients (18 males, 14 females; aged 20 to 60 years, mean 48.67±12.25 years) with a mean duration of PD of 46.80 months were included. There was a significant difference of retinal thickness in the nasal, inferior and superior quadrants between controls and PD patients (p < 0.05). Vitamin D supplementation was linked to increased retinal thickness in macula superior, nasal and inferior quadrants (p<0.05). There was a positive correlation between retinal thickness in macula central and temporal with residual renal function (p=0.006, p=0.019). Higher urea and total cholesterol levels were found to be linked to higher retinal thickness in central, nasal, temporal and macula central (p<0.05).
Conclusion: OCT revealed a significant reduction of retinal thickness in PD patients.
I have been working as a nephrologist in Turkey and will be working in Sydney University for one year as ISN fellow. (June 2018-2019)