SPLENIC INFARCTS AND PULMONARY RENAL SYNDROME IN A YOUNG PATIENT WITH DOUBLE-POSITIVE ANTI-GBM AND ANCA-ASSOCIATED VASCULITIS: CASE REPORT

A ALHABOBI¹, F RAJAH², N ALOUDAH³, A OSMAN⁴, E WALEED ELHASSAN⁵

¹National Guard Hospital, Kind Abdulaziz Medical City, Riyadh, Saudi Arabia, ²National Guard Hospital, Kind Abdulaziz Medical City, Riyadh, Saudi Arabia, ³National Guard Hospital, Kind Abdulaziz Medical City, Riyadh, Saudi Arabia, ⁴National Guard Hospital, Kind Abdulaziz Medical City, Riyadh, Saudi Arabia, ⁵National Guard Hospital, Kind Abdulaziz Medical City, Riyadh, Saudi Arabia

Double-positive disease (DPD), defined by double-seropositivity for serum anti-glomerular basement membrane (GBM) antibodies and anti-neutrophil cytoplasmic antibodies (ANCA) is a rare cause of pulmonary renal syndrome. Here, we present an exceptional course of a 20-year-old male with seropositivity for anti-myeloperoxidase ANCA (MPO-ANCA), anti-GBM antibody, who presented first with renal impairment due to focal necrotizing crescentic glomerulonephritis. After receiving treatment, he presented two years later with a relapse manifesting with diffuse alveolar hemorrhage and multiple splenic infarcts. We discuss the clinical presentation patterns and treatment strategies of this entity.

Biography:
A Fourth year Internal Medicine resident training in King Abdulaziz Medical City, Riyadh, Saudi Arabia