LEFT VENTRICULAR REMODELING IN DIALYSIS PATIENTS IN TASHKENT REGION OF UZBEKISTAN

O SHARAPOV B DAMINOV 1,2

1Tashkent Pediatric Medical Institute, Tashkent, Uzbekistan, 2Republican Specialized Scientific Practical Medical Center of Nephrology and Kidney transplantation, Tashkent, Uzbekistan

Aim: To study the remodeling of the left ventricle(LV) of the heart in CKD 5D patients in Tashkent region of Uzbekistan.

Background: LV hypertrophy is an independent risk factor for death in dialysis patients with CKD. In Uzbekistan at the moment there are about 3000 people in need of hemodialysis and most of them are in Tashkent region of the country.

Methods:104 (51 men and 53 women) CKD 5D patients permanently resided in Tashkent were examined. The average age of the surveyed was 49.7±11.7 years. The main initial diseases were glomerulonephritis (36.5%, n = 38), diabetes mellitus (31.7%, n = 33%) and urolithiasis (10.6%, n = 11). The average duration of HD was 37.0±4.77 months. LV  hypertrophy was diagnosed with LVMI values equal to or exceeding normal values.

Results: The study showed concentric hypertrophy, eccentric hypertrophy, and concentric LV remodeling. Normal LV geometry was not determined in any patient. 62(59.6%) patients had concentric LV myocardial hypertrophy, 10(9.6%) patients had concentric LV remodeling, 32(30.8%) patients had eccentric LV hypertrophy. Indicators of IVS thickness averaged 13.0±2.1 mm, PWLV thickness 12.1±2.0 mm, LVM 310.8±22.73 g, LVMI 169.6±12.26 g/m2.

Conclusion: All studied CKD 5D patients in Tashkent region had LV remodeling. More than 90% of the examined patients had LV hypertrophy. The most common are concentric remodeling (59.6%) and eccentric remodeling (30.8%) of the left ventricle..


Biography:

I studied at the Tashkent Medical Academy during 2004-2011. Received a Master’s degree from the Tashkent Medical Academy in 2014. Since 2014 I have been working at the Department of Internal Medicine of the Tashkent Pediatric Medical Institute. Since 2018, I also began to work at the Republican Specialized Scientific Practical Medical Center of Nephrology and Kidney transplantation as a PhD fellow.

Member of the ASN, ISN, ERA-EDTA, Russian Dialysis Society. National Representative of ERA-EDTA Young Nephrologists Platform. Regional representative of the ISN NIS and Russia region. Numerous participant in international conferences as a speaker (+ ANZSN ASM 2020).

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