HISTOPATHOLOGICAL TYPES AND CLINICAL CHARACTERISTICS OF LUPUS NEPHRITIS PATIENTS AT RSUP DR. KARIADI SEMARANG

Nugroho Y1, NURANI A1, PARTININGRUM D1, ARWANTO A1, LESTARININGSIH1, CHASANI S1

1Division of Nephrology, Department of Internal Medicine, Dr. Kariadi Hospital, Semarang, , Indonesia

Aim: To identify demographic distribution and clinical features of lupus nephritis patients among histopathological groups.

Background: Lupus nephritis is common among systemic lupus erythematosus patients. An abnormal urinalysis and sometimes elevated plasma creatinine concentration is present in a large proportion of patients at the time of diagnosis of lupus nephritis. Systemic lupus erythematosus with lupus nephritis has poor prognosis.

Methods: A retrospective study was done among patients who underwent kidney biopsy at the Dr. Kariadi General Hospital from January 2019 to December 2020. We evaluate data of age, gender and urinalysis. We also collected patient’s data whose histopathological examination confirmed as lupus nephritis.

Result: fifty six patients who underwent kidney biopsy included in the study. Most 38 (67.86%) of the patients were female (mean age 30.53 years). Class III lupus nephritis was the most common with 20 patients (35.71%) feature on histopathological findings, followed by class IV with 16 patients (28.58%) and class II with 10 patients (17.86%). There were 5 patients had overlapping pattern. Symptoms of nephrotic syndrome and hematuria were found in class IV with 14 of 16 patients (87%) and  16 of 20 patients (80%) in class III.

Conclusion: class III and IV are the most histopathological findings and nephrotic syndrome and haematuria are usually found in class IV and V of lupus nephritis.

Keywords: lupus nephitis, histopathology type, clinical features, proteinuria, hematuria


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