SITUMORANG D1, Nurani A1, Partiningrum D1, Lestariningsih L1, Arwanto A1, Chasani S1
1Nephrology and Hypertension Division, Department of Internal Medicine, Dr. Kariadi Hospital, Semarang, Indonesia
Background: One of organ complications in systemic lupus erythematosus (SLE) is lupus nephritis. Urinalysis abnormalities, with or without elevated anti-DsDNA, are typical in lupus nephritis at the time of diagnosis. The aim of this research is to find out whether there is correlation between anti-DsDNA and degree of proteinuria in lupus nephritis.
Methods: This is a retrospective study which evaluated kidney biopsy at Dr. Kariadi General Hospital between January 2019 and December 2020. We also collected information on age, gender, urinalysis, and anti-DsDNA levels. We gathered histopathological findings of those whose clinically confirmed as lupus nephritis.
Result: We included data from 56 patients, and only 33 had complete data, consisted of 16 (51.5 %) females. Histopathological features showed that the most frequent histopathological class were 16 (48.5%) class III, followed by 8 (24.2%) class II. Proteinuria 3+ was the most frequent symptom contributing for 12 (36.4%) of samples. There was no correlation between anti-dsDNA levels and the degree of proteinuria (r= <0,005, p=0,15).
Conclusion: There is no correlation between Anti-DsDNA levels and the degree of proteinuria in lupus nephritis.
Keywords: lupus nephritis, histopathology type, clinical features, proteinuria
Biography:
Born: Jakarta, November 19th 1986
Education:
Faculty of Medicine, Universitas Kristen Indonesia, General Physician – 2011
Faculty Of Medicine, Universitas Sumatera Utara, Internist- 2019
Faculty of Medicine, Universitas Diponegoro, Nephrology and Hypertension Trainee Program
Work:
Dr. Kariadi Hospital, Semarang, Indonesia
Internal Medicine Departement, Universitas Kristen Indonesia Hospital
Member of:
Indonesian Medical Association
Indonesian Society of Internal Medicine
Indonesia Society of Nephrology
Indonesian Society of Ultrasound in Medicine
International Society of Nephrology