CORRELATION BETWEEN ANTI-DSDNA LEVELS AND DEGREE OF PROTEINURIA IN LUPUS NEPHRITIS PATIENTS

SITUMORANG D1, Nurani A1, Partiningrum D1, Lestariningsih L1, Arwanto A1, Chasani S1

1Nephrology and Hypertension Division, Department of Internal Medicine, Dr. Kariadi Hospital, Semarang, Indonesia

Background: One of organ complications in systemic lupus erythematosus (SLE) is lupus nephritis. Urinalysis abnormalities, with or without elevated anti-DsDNA, are typical in lupus nephritis at the time of diagnosis. The aim of this research is to find out whether there is correlation between anti-DsDNA and degree of proteinuria in lupus nephritis.

Methods: This is a retrospective study which evaluated kidney biopsy at Dr. Kariadi General Hospital between January 2019 and December 2020. We also collected information on age, gender, urinalysis, and anti-DsDNA levels. We gathered histopathological findings of those   whose clinically confirmed as lupus nephritis.

Result: We included data from 56 patients, and only 33 had complete data, consisted of 16 (51.5 %) females. Histopathological features showed that the most frequent histopathological class were 16 (48.5%) class III, followed by 8 (24.2%) class II. Proteinuria 3+ was the most frequent symptom contributing for 12 (36.4%) of samples. There was no correlation between anti-dsDNA levels and the degree of proteinuria (r= <0,005, p=0,15).

Conclusion: There is no correlation between Anti-DsDNA levels and the degree of proteinuria in lupus nephritis.

Keywords: lupus nephritis, histopathology type, clinical features, proteinuria


Biography:

Born: Jakarta, November 19th 1986

Education:

Faculty of Medicine, Universitas Kristen Indonesia, General Physician – 2011

Faculty Of Medicine, Universitas Sumatera Utara, Internist- 2019

Faculty of Medicine, Universitas Diponegoro, Nephrology and Hypertension Trainee Program

Work:

Dr. Kariadi Hospital, Semarang, Indonesia

Internal Medicine Departement, Universitas Kristen Indonesia Hospital

Member of:

Indonesian Medical Association

Indonesian Society of Internal Medicine

Indonesia Society of Nephrology

Indonesian Society of Ultrasound in Medicine

International Society of Nephrology

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