LOW SERUM ALBUMIN AND THE RISK OF PERITONEAL DIALYSIS-ASSOCIATED PERITONITIS

D SUDARMANTO 1, H PRASANTO 1, I KUSWADI 1, M PUSPITASARI 1, Y WARDHANI 1

1Division of Nephrology and Hypertension, Departement of Internal Medicine, Sardjito General Hospital, Yogyakarta, Indonesia

Aim:To identify the risk factor contributed to peritoneal dialysis (PD)-associated peritonitis.

Background: Peritonitis is associated with an increasing morbidity and mortality rate in peritoneal dialysis patients. A number of peritonitis cases result in hypoalbuminemia, and in other cases, peritonitis follows a decline in the serum albumin level. Albumin is a major serum protein that plays a vital physiological function, including the maintenance of colloidal osmotic pressure. Albumin not only as a nutritional marker but also an indicator of peritonitis.

Methods: Observational study using secondary data based on medical records included 75 end-stage renal disease (ESRD) patients receiving PD therapy from Dr. Sardjito Hospital, January – December 2020. Patients were categorized into two groups: peritonitis group (n = 18) and non-peritonitis group (n = 57). PD-associated peritonitis was diagnosed based on guidelines recommended by the International Society for Peritoneal Dialysis.

Results:The most frequently identified pathogen was Gram-positive cocci (61,11 %). Univariate and multivariate analysis showed that serum albumin (OR 8.364, 95% CI 2.569-27.226 ; p= 0.001) was significantly correlated with PD-associated peritonitis. Receiver operating characteristic (ROC) curves showed that the areas under the curve was 0.728 with optimal cut-off values of 3.235 g/dL for serum albumin.

Conclusion:Low serum albumin increased the risk of PD-associated peritonitis. Gram-positive coccus is the major pathogen responsible for PD-associated peritonitis.


Biography:

My name is Doddy Sudarmanto, was born in Bogor at September 16, 1974, Graduated  from Medical Faculty of Christian University of Indonesia, at 2002.  Graduated Internal Medicine from  University of Gadjah Mada at 2015.

Now, I am trainee of Nephrology and Hypertension sub specialization study program, Internal Medicine, Faculty of Medicine-Public Health and Nursing, University of Gadjah Mada , Yogyakarta, Indonesia

 

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