SEX MATTERS: GENDER-RELATED DIFFERENCE IN RENAL REPLACEMENT THERAPY (RRT) INCIDENCE RATES

SP MCDONALD

ANZDATA Registry, Adelaide, South Australia 2Central Northern Adelaide Renal and Transplantation Service, Adelaide, South Australia, 3University of Adelaide, Adelaide, Australia

Aim: Examine changes in RRT incidence by gender

Background: The steady increase in RRT incidence and then stabilisation in recent years are well known. However, detailed changes in incidence with gender in Australia have not been examined or reported previously.

Methods: Using the ANZDATA Registry, rates of new renal replacement therapy were calculated for the period 1971-2015 by year, classified by gender, primary renal disease, and age at RRT start.

Results: For the period 1971-5 the Male:Female ratio (MFR) was 1.13 [95% CI 1.03-1.24]. Over time this has progressively increased to 1.65 [1.59-1.70] over the period 2011-5. These trends differed by age groups. Over 2011-5, MFR for 25-44 age group was 1.33 [1.21-1.46]; for >=75 year old group 2.77 [2.56-3.01]. Differences were also seen with primary renal disease: for diabetic nephropathy MFR was 1.92 [1.80-2.05] and glomerulonephritis 1.92 [1.76-2.10]. For polycystic disease, MFR was 1.48 [1.27-1.73].

Conclusions: There is a growing male excess among people starting RRT. This may reflect rates of disease prevalence, but the polycystic disease difference suggests differential dialysis uptake in addition.

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